Academic trends-cosunter

2017-12-06 Significance of Day-1 Viral Response of Hepatitis C Virus in Patients with Chronic Hepatitis C Receiving Direct-acting Antiviral Therapy
We evaluated the significance of very early viral response after the start of therapy, which indicates direct HCV response to the drugs, on therapeutic outcome.

keys：Hepatitis C Virus　Direct-acting Antivirals　Sustained Virologic Response　
2017-11-29 Contrast Enhanced Ultrasound Identifies Hepatocellular Carcinoma in Cirrhosis: A Large Multicenter Retrospective Study
The American College of Radiology has recently released a scheme (CEUS LI-RADS) classifying lesions at risk for HCC investigated by CEUS.

keys： LR-5 CEUS　HCC　Diagnosis　
2017-11-22 High Risk of Hepatocellular Carcinoma and Death in Patients with Immune-Tolerant-Phase Chronic Hepatitis B
High serum HBV DNA levels are associated with high risks of hepatocellular carcinoma (HCC) and cirrhosis in patients with chronic hepatitis B (CHB).

keys：Immune-tolerant Phase　Immune-active Phase　Antiviral Intervention　
2017-11-15 Upregulation of DARS2 by HBV Promotes Hepatocarcinogenesis Through the miR-30e-5pMAPKNFAT5 Pathway
The osmoregulatory transcription factor nuclear factor of activated T-cells 5 (NFAT5) has been shown to play an important role in the development of many types of human cancers.

keys：NFAT5　HCC　Suppress　
2017-11-08 Efficacy of NVR 3-778, Alone and in Combination With Pegylated Interferon, vs Entecavir in uPASCID Mice With Humanized Livers and HBV Infection
NVR3-778 has high antiviral activity in mice with humanized livers and stable HBV infection, reducing levels of serum HBV DNA and HBV RNA.

keys：NVR 3-778　Peg-IFN　HBV Infection　
2017-11-01 Long-Term Outcome of Hepatitis B Virus-Related Chronic Hepatitis Under Protracted Nucleos(t)ide Analogues
Development of cirrhosis, events of liver decompensation and hepatocellular carcinoma (HCC) during the follow-up were the main endpoints, as the complication-free survival.

keys：HBV　NUCs　HCC　
2017-10-25 Why Do I Treat HBeAg-Positive Chronic Hepatitis B Patients with a Nucleoside Analogue
Sustained suppression of HBV replication is the cornerstone for preventing the progression of disease and prolonging survival in patients with CHB.

keys：Nucleoside Analogues 　Chronic Hepatitis B　Suppression of HBV　
2017-10-18 Comprehensive Circular RNA Profiling Reveals the Regulatory Role of the CircRNA-100338miR-141-3p Pathway in Hepatitis B-Related Hepatocellular Carcinoma
Circular RNAs (circRNAs) represent a class of endogenous noncoding RNAs that have recently been recognized as important regulators of gene expression and pathological networks.

keys：circRNAs　HCC　biomarker　
2017-10-11 Efficacy and Safety of Tenofovir Disoproxil Fumarate in Preventing Vertical Transmission of Hepatitis B in Pegnancies with High Viral Load
The available evidence suggests that TDF is effective and safe in preventing vertical transmission of hepatitis B in pregnancies exhibiting a high viral load.

keys：TDF　Pregnancies　HBV　
2017-09-27 The Efficacy and Safety of Tenofovir in The Prevention of Hepatitis B Virus Recurrence Following Liver Transplantation
The results of this study, after a 36-month follow-up period, were encouraging and demonstrated that TDF therapy is safe and efficacious in treating HBV-positive organ transplant patients.

keys：TDF Therapy　HBV-positive　Organ Transplant

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